Modelling to understand the potential impact of ivermectin on malaria transmission

Modelling to understand the potential impact of ivermectin on malaria transmission

Objectives

To investigate the potential impact of mass IVM distribution coadministered with mass screening and treatment or MDA on malaria transmission in different malaria-endemic settings. The effect of IVM on mosquito mortality will be modelled in a 3-stage process: first, the pharmacokinetic profile of the drug will be estimated using data from the published literature. Second, a proportional hazards survival model will be fitted to vector survival data, incorporating the pharmacokinetic profile of IVM as a covariate. Finally, this will be incorporated into an existing malaria transmission model.

PI Institution(s)

Principal Investigator (PI)

Funding source(s)

Abstract

Ivermectin (IVM), used alongside mass treatment strategies with an artemisinin combination therapy, has been suggested as a possible tool for reducing malaria transmission. Mosquitoes ingesting a bloodmeal containing IVM have increased mortality, reducing the probability that the parasite completes sporogony.

Key facts

  • Dates
    Oct 2012 to Oct 2015

MESA tags

  • Methodology
    Entomology, Modelling
    Theme(s)
    Drug-based strategies, Impact of interventions, Measurement of transmission, Tools for elimination