Impact of population based Indoor Residual Spraying (IRS) in combination with chemotherapy on key malaria indicators in a high transmission setting in north eastern Uganda (Katakwi Rotary Malaria Project -KRMP-)

Impact of population based Indoor Residual Spraying (IRS) in combination with chemotherapy on key malaria indicators in a high transmission setting in north eastern Uganda (Katakwi Rotary Malaria Project -KRMP-)

Objectives

To evaluate the impact of population based IRS in combination with MDA on key malaria indicators in a high transmission setting in North-Eastern Uganda.

Primary outcomes measured:

  • Prevalence of asexual parasitemia in the community
  • Parasite positivity rate at health facilities in the community
  • Entomological Inoculation Rate
  • Acceptability of various interventions

Methodology: To deploy 4 rounds of the intensive combination of Indoor Residual Spraying and Mass Drug Administration at the same time.

Interventions:

  • a) IRS years 1-2,
  • b) chemotherapy years 1-2 (DP will be used in combination with IRS. It will be administered in two ways, depending on participant's age: six rounds of intermittent preventive treatment for children aged 4 months to 17 years at 1, 4 and 6 monthly intervals; MSAT for malaria adults,
  • c) active case detection and treatment at year 3 of all malaria cases.

PI Institution(s)

Funding source(s)

Partner(s)

Abstract

In Katakwi, most families live by subsistence farming, and malaria transmission rates are staggeringly high. A baseline survey showed that almost half of kids under the age of five were infected with the parasite. In 2008-09, a pilot program suggested that an innovative combination of interventions could crash the parasite population and decrease malaria prevalence by 90%. Now, Pilgrim Africa is scaling it up. This operational research project follows three sub-counties over 3.5 years. More than 40,000 people will benefit. Computer modelling suggests that by deploying Indoor Residual Spraying and Mass Drug Administration at the same time, we will reap twice the benefit than we would if we deployed them one after another. Four rounds of this intensive combination will crash the parasite population in both its mosquito and human hosts, dramatically reducing transmission rates.

Katakwi Rotary Malaria Project

Key facts

  • Dates
    Apr 2016 to Apr 2020
    Funding amount
    $2,588,301
    Funding information
    BMGF Grant OPP1148566, Rotary Global Grant
    Country
    • Uganda

MESA tags

  • Methodology
    Operational research
    Theme(s)
    Drug-based strategies, Elimination strategies, Tools for elimination