Functional analysis of the Plasmodium falciparum cGMP-dependent protein kinase

Functional analysis of the Plasmodium falciparum cGMP-dependent protein kinase

Objectives

Cyclic GMP signaling mediated by the cGMP-dependent protein kinase (PKG) plays important roles in several stages of the malaria parasite life-cycle. This study aims to identify the molecular mechanisms by which PfPKG mediates release of malaria parasites from red blood cells.

PI Institution(s)

Principal Investigator (PI)

Funding source(s)

Partner(s)

Key facts

  • Dates
    May 2012 to Apr 2015
    Country
    • United States

MESA tags

  • Methodology
    Basic science
    Theme(s)
    Parasite genetic diversity