Fast Elimination of Malaria by Source Eradication (FEMSE) Project

Fast Elimination of Malaria by Source Eradication (FEMSE) Project

Objectives

To investigate the therapeutic effect of the method of Fast Elimination of Malaria by Source Eradication (FEMSE), through Mass Drug Administration (MDA) campaigns in Anjouan Island (2012) and Grande Comore Island (2013).

Secondary objectives in Anjouan Island:

  • To investigate whether 3 monthly rounds of MDA regimens of ACT (Artemisinin–piperaquine), with or without low-dose primaquine can quickly block malaria transmission in Anjouan Island
  • To investigate whether MDA regimens of ACT, with or without low-dose primaquine can increase or decrease the risk of drug resistance
  • To examine how the benefits of the individual drugs (low-dose primaquine) balance against the liabilities of their use and attendant possibilities of adverse events, including the risks and contraindications of primaquine in conditions of G6PD-deficiency and early pregnancy
  • To investigate in which settings can the inclusion of low-dose primaquine as a gametocidal drug improve MDA outcomes

Secondary objectives in Grande Comore Island:

  • To investigate whether MDA regimens of ACT (Artemisinin–piperaquine) can quickly block malaria transmission in Grande Comore Island
  • To examine whether MDA regimens of ACT can increase or decrease the risk of drug resistance in Grande Comore Island

PI Institution(s)

Principal Investigator (PI)

Funding source(s)

Abstract

Artemisinin–piperaquine, with or without Primaquine, was administered in 3 monthly rounds from October to December 2012 across Anjouan Island, Union of Comoros. Plasmodium falciparum malaria rates, mortality, parasitemias, adverse events, and PfK13 Kelch-propeller gene polymorphisms were evaluated.

Steep reductions of malaria cases were achieved suggesting potential for highly successful MDA in the epidemiological settings such as those on Anjouan. A major challenge is to sustain and expand the public health benefits of malaria reductions by MDA.

Project on Fast Control and Elimination of Malaria by Source Eradication Pilot Study on Mass Drug Administration by using Artemisinin-based Combination Therapy in Anjouna, Comoros

In Grande Comore Island, 3 monthly rounds of Artemisinin-Piperaquine were deployed from October to December 2013. Plasmodium falciparum malaria rates, mortality, parasitemias, adverse events, and PfK13 Kelch-propeller gene polymorphisms were evaluated.

Key facts

  • Dates
    2012 to 2014
    Funding information
    China-UK Global Health Support Programme
    Country
    • Comoros

MESA tags

  • Methodology
    Epidemiology
    Theme(s)
    Drug-based strategies, Elimination strategies