Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product

Evaluation of a Novel Long Lasting Insecticidal Net and Indoor Residual Spray Product

Objectives

The proposed study is a four-arm randomized control trial (RCT) in 48 villages in the Lakes region in Tanzania comparing the relative effectiveness of 4 vector control interventions for reducing malaria transmission and controlling vector populations in an area where An gambiae s.s is pyrethroid and carbamate resistant:

1/ a standard long lasting insecticidal net (LLIN),

2/ a LLIN which incorporates a piperonyl butoxide (PBO) synergist,

3/ a long lasting indoor residual spray (IRS) formulation used in conjunction with standard pyrethroid LLIN or

4/ the long lasting indoor residual spray (IRS) formulation used in conjunction with the LLIN which incorporates a PBO synergist.

PI Institution(s)

Principal Investigator (PI)

Funding source(s)

Partner(s)

Abstract

The proposed trial will demonstrate whether the novel LLIN and long lasting IRS formulation will be more effective for controlling An.gambiae s.s. and reducing malaria prevalence than current practice with the conventional LLIN. There is great interest in conducting this trial. Alternative vector control products are limited and most new insecticides are not suitable for use on LLINs or as IRS.

The trial will provide epidemiological, entomological, economic and social evidence of impact, as the investigators shall be measuring the reductions in malaria prevalence and malaria transmission rates EIR, and changes in the frequency of resistance, mosquito species ratios and economic cost effectiveness.

http://ClinicalTrials.gov/show/NCT02288637

Key facts

  • Dates
    Mar 2014 to Aug 2016
    Funding amount
    $3,175,070
    Country
    • Tanzania, United Republic of

MESA tags

  • Methodology
    Entomology, Operational research, Product development & clinical research
    Theme(s)
    Impact of interventions, Insecticide resistance, Tools for elimination