Evaluating the feasibility and effectiveness of Reactive Targeted Parasite Elimination vs. Reactive Case Detection as a community level intervention in response to a passively identified index case: a cluster randomised controlled trial in Swaziland

Evaluating the feasibility and effectiveness of Reactive Targeted Parasite Elimination vs. Reactive Case Detection as a community level intervention in response to a passively identified index case: a cluster randomised controlled trial in Swaziland

Objectives

Primary aim: To compare the impact of TPE (Targeted Parasite Elimination) versus RACD (Reactive Case Detection) on malaria incidence.
Secondary aims: Effectiveness:

1. To compare the impact of TPE versus RACD on seroprevalence.

2. To compare the impact of TPE versus RACD on prevalence of infection.

3. To compare the impact of TPE versus RACD on proportion of imported incident cases.

4. To compare the impact of TPE versus RACD on time to first post-intervention incident local case.

5. To compare the impact of TPE versus RACD on transmission potential as measured by relatedness of infections by microsatellite genotyping.

Feasibility:

1. To determine the feasibility of reaching 80% coverage for TPE versus RACD.

2. To evaluate the safety of TPE versus RACD.

3. To compare the acceptability of TPE versus RACD.

4. To compare the costs and cost-effectiveness of TPE versus RACD.

5. To measure the adherence to modified DOT regimen in the TPE arm.

PI Institution(s)

Principal Investigator (PI)

Funding source(s)

Partner(s)

Key facts

  • Dates
    Jan 2014 to Dec 2016
    Funding amount
    $1,268,800
    Country
    • Swaziland

MESA tags

  • Methodology
    Operational research
    Theme(s)
    Drug-based strategies, Elimination strategies, Foci, Surveillance