Elimination of Plasmodium falciparum in an area of multi-drug resistance

Elimination of Plasmodium falciparum in an area of multi-drug resistance

Objectives

In response to a large number of malaria cases reported in three remote villages on the Thai-Myanmar border where malaria is endemic and the disease is seasonal, surveys were conducted using an ultra-sensitive qPCR assay (LOD 22 parasites per mL). In one of the villages where it was feasible, mass anti-malarial drug administration (MDA) was proposed to the population as a potential solution, and this was adopted.

PI Institution(s)

Partner(s)

Abstract

Resistance to the artemisinin derivatives in Plasmodium falciparum has emerged in Cambodia and is now spreading throughout South-East Asia. The rapid elimination of P. falciparum seems to be the only viable option to avoid a public health disaster but this is difficult because even in low transmission settings many residents have asymptomatic parasitaemias.

 

Key facts

  • Dates
    2012 to 2013
    Country
    • Myanmar
    • Thailand

MESA tags

  • Methodology
    Epidemiology
    Theme(s)
    Drug-based strategies, Elimination strategies, Vulnerable populations