Effectiveness of Mass Drug Administration (MDA) for Reducing Seasonal Malaria Transmission Towards Its Elimination in Hotspot Areas in Zanzibar - a Cluster-randomised Controlled Trial (MaDrAZ)

Effectiveness of Mass Drug Administration (MDA) for Reducing Seasonal Malaria Transmission Towards Its Elimination in Hotspot Areas in Zanzibar - a Cluster-randomised Controlled Trial (MaDrAZ)

Objectives

The main objective is to determine the effectiveness of two rounds of mass drug administration (MDA) with dihydroartemisinin-piperaquine + single low dose primaquine for reducing seasonal malaria transmission in Shehias considered hotspots on Unguja Island, Zanzibar.

The secondary objectives are to determine MDA coverage, compliance, and safety after one and two rounds of MDA.

PI Institution(s)

Principal Investigator (PI)

Funding source(s)

Partner(s)

Abstract

Cluster randomized control trial consisting of 2 rounds of Mass Drug Administration 4 weeks apart. the drugs used are Dihydroartemisinin-piperaquine + primaquine (single low dose, 0.25mg/kg) through house-to-house campaigns.

In both arms, there will be the distribution of LLINs, IRS and passive case detection of individuals seeking treatment at local health facilities. 16 hotspot Shehias (8 Shehias randomly allocated to each arm) will be selected in three districts (West, Central and South) in Unguja Island, Zanzibar, with an estimated enrollment of 24000 individuals. 

Outcome measures:

(Primary)

  • Cumulative notified malaria incidence in the MDA and control Shehias 6 months after second round of MDA

(Secondary)

  • PCR determined community prevalence of Plasmodium infections in the MDA and control Shehias at baseline and 6 months after second round of MDA
  • Population coverage of the MDA intervention at each round
  • Proportion of population receiving two rounds of MDA
  • Population compliance to the MDA intervention at each round
  • Occurence of adverse events after MDA
  • Cumulative notified malaria incidence in the MDA and control Shehias during the following high transmission season 15 months after second round of MDA

MaDrAZ

Key facts

  • Dates
    2016 to 2016
    Country
    • Tanzania, United Republic of

MESA tags

  • Methodology
    Epidemiology
    Theme(s)
    Drug-based strategies, Elimination strategies, Tools for elimination