Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria (PACKNOW)

Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria (PACKNOW)

Objectives

To assess the effect of paracetamol on renal function and oxidative stress in patients with knowlesi malaria

PI Institution(s)

Principal Investigator (PI)

Funding source(s)

Partner(s)

Abstract

Official title: Effect of Paracetamol on Renal Function in Plasmodium Knowlesi Malaria: A Randomised Controlled Clinical Trial

Plasmodium knowlesi is the most common cause of malaria, and malaria deaths, in Sabah, Malaysia. Acute kidney injury (AKI) is a common feature of severe knowlesi malaria; however, the mechanisms of AKI in knowlesi malaria are unknown. In falciparum malaria, recent evidence suggests that oxidative stress from haemolysis-related cell-free haemoglobin (CFHb) may contribute to the pathogenesis of AKI.

The investigators hypothesise that paracetamol may provide renal protection in patients with severe knowlesi malaria by reducing the hemoprotein-induced lipid peroxidation that occurs in haemolytic conditions. As there is currently no consensus that exists concerning adequate medical treatment for severe malaria complicated by intravascular haemolysis and AKI, the potential application of paracetamol would be of great benefit, especially as it is safe and widely available.

The main activity proposed is a randomised, open-label, controlled trial of regularly-dosed paracetamol, versus no paracetamol, in patients with knowlesi malaria, to assess the effect of paracetamol on renal function and oxidative stress. 

https://clinicaltrials.gov/ct2/show/study/NCT03056391

Key facts

  • Dates
    Oct 2016 to Aug 2018
    Country
    • Malaysia

MESA tags

  • Methodology
    Product development & clinical research