"Title","URL","Type","Start year","End year","Countries","Project funding","Funding source(s)","Funding information","Partner(s)","PI institution(s)","Principal investigator","Abstract","Objectives","Methodology","Themes"
"Defining mosquito-to-man transmission of P. falciparum and P. vivax: Evaluation of epidemiological, molecular and serological markers in longitudinal cohorts in Brazil, Thailand, Solomon Islands and Papua New Guinea (based on TransEPI Consortium)","http://www.malariaeradication.org/mesa-track/defining-mosquito-man-transmission-p-falciparum-and-p-vivax-evaluation-epidemiological","Project","Jan 2013","Apr 2016","Papua New Guinea, Solomon Islands, Brazil, Thailand","$193 150","Malaria Eradication Scientific Alliance (MESA)","","Barcelona Institute for Global Health (ISGlobal), Mahidol University, Papua New Guinea Institute of Medical Research (IMR), Swiss Tropical and Public Health Institute (Swiss TPH) , Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Walter and Eliza Hall Institute of Medical Research (WEHI)","Ivo Mueller","","To investigate the performance of classical epidemiological, molecular and serological measures as markers of recent exposure (as measured by molFOI) in 5 cohorts conducted at moderate, low and very low transmission intensity.
To determine the molecular force of P. falciparum (Pf) and P. vivax (Pv) blood-stage infections (molFOI) and their relationship with age, transmission season, spatial variation, intervention coverage, incidence of clinical episodes and prevalence, incidence density and multiplicity/genetic complexity of infection.
To measure antibody levels to a panel of Pf and Pv blood-stage antigens and relate antibody prevalence and titre to epidemiological and molecular measures of transmission.
To investigate the performance of epidemiological, molecular and serological markers of mosquito-to-man transmission for identification of hot-spots of recent transmission in areas with moderate, low and very low transmission intensity.
","Basic science, Epidemiology","Measurement of transmission, Parasite genetic diversity"
"Identification of serological markers for P. vivax","http://www.malariaeradication.org/mesa-track/identification-serological-markers-p-vivax","Project"," 2014"," 2016","Papua New Guinea, Brazil, Thailand","$700 000","FIND","","Mahidol University, Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil, Papua New Guinea Institute of Medical Research (IMR), Ehime University, Japan , QIMR Berghofer Medical Research","Walter and Eliza Hall Institute of Medical Research (WEHI)","Ivo Mueller","","To identify serological markers for detection of P. vivax recent infection.","Basic science, Epidemiology","Measurement of transmission, P. vivax"
"PregVax: cohort observational study in pregnant women in five P. vivax endemic countries","http://www.malariaeradication.org/mesa-track/pregvax-cohort-observational-study-pregnant-women-five%C2%A0p-vivax%C2%A0endemic-countries","Project","Mar 2008","Aug 2012","Guatemala, Papua New Guinea, Brazil, Colombia, India","$6 310 427","Seventh Framework Programme of the European Union (FP7), Malaria in Pregnancy (MiP) Consortium , Ministry of Science and Innovation, Spain (MICINN)","The main funder EC FP7 awarded 5,934,110 USD, The Spanish Minstry of Science and Innovation awarded 312,726 USD, and The Malaria in Pregnancy Consortium awarded 63,591.00 USD","Centers for Disease Control and Prevention (CDC), USA, Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil, National Institute of Immunology, Colombia, International Center for Genetic Engineering and Biotechnology (ICGEB), India , Karolinska Institute, National Institute of Health (ISS), Italy , Papua New Guinea Institute of Medical Research (IMR), Sardar Patel Medical College, India, University of the Valley of Guatemala, University of Melbourne","Barcelona Institute for Global Health (ISGlobal)","Clara Menéndez","","The main objective of the PregVax study is to describe the epidemiological and clinical features of P. vivax malaria infection in pregnancy.  The PregVax study also aims to determine if there are pregnancy-specific immune responses and characterize, genotypically and phenotypically, parasites of the placenta.","Epidemiology","P. vivax, Vulnerable populations"
"Plasmodium vivax: molecular basis of severe pathology and development of a reticulocyte-derived exosome nanovesicle vaccine","http://www.malariaeradication.org/mesa-track/plasmodium-vivax-molecular-basis-severe-pathology-and-development-reticulocyte-derived","Project","Jan 2013","Dec 2015","","$250 244","Ministry of Economy and Competitiveness (MINECO), Spain","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Barcelona Institute for Global Health (ISGlobal)","Hernando A. Del Portillo Obando","","","Basic science, Product development & clinical research","P. vivax"
"The TransEPI Consortium, malaria transmission dynamics","http://www.malariaeradication.org/mesa-track/transepi-consortium-malaria-transmission-dynamics","Project","Nov 2011","Nov 2015","Papua New Guinea, Brazil, Thailand","$3 568 109","Bill & Melinda Gates Foundation (BMGF)","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil, Mahidol University, Papua New Guinea Institute of Medical Research (IMR), Swiss Tropical and Public Health Institute (Swiss TPH) , Walter and Eliza Hall Institute of Medical Research (WEHI)","Barcelona Institute for Global Health (ISGlobal)","Ivo Mueller","","To determine the dynamics of malaria transmission stages in host and vector in 3 non-African settings and determine bottlenecks and their impact on transmission and parasite population diversity. To compare the epidemiology of P. falciparum & P. vivax transmission in Papua New Guinea, Thailand and Brazil.","Epidemiology","P. vivax"
"Research program on Plasmodium vivax malaria","http://www.malariaeradication.org/mesa-track/research-program-plasmodium-vivax-malaria","Core investment"," 2007"," 2011","","","Cellex Foundation","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil, International Center for Genetic Engineering and Biotechnology (ICGEB), India , National Institute of Immunology, Colombia, Papua New Guinea Institute of Medical Research (IMR), Sardar Patel Medical College, India","Barcelona Institute for Global Health (ISGlobal)","Pedro Alonso","","","Basic science","P. vivax"
"Epidemiology of ultra-low density malaria infections and their relevance for control and elimination","http://www.malariaeradication.org/mesa-track/epidemiology-ultra-low-density-malaria-infections-and-their-relevance-control-and","Project","","","Papua New Guinea, Brazil, Thailand","$500 000","Swiss National Science Foundation (SNSF)","","Walter and Eliza Hall Institute of Medical Research (WEHI), Papua New Guinea Institute of Medical Research (IMR), Mahidol University, Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Swiss Tropical and Public Health Institute (Swiss TPH) ","Ingrid Felger","","The specific objectives are:
1. To measure the proportion of parasites missed by microscopy and standard PCR in field surveys.
2. To examine how host age and levels of malaria endemicity influence this proportion.
3. To determine whether ultra-low density infections carry gametocytes and estimate their contribution to the human reservoir of infection to mosquitoes.
4. To find ways to increase the sensitivity of parasite detection in large scale field surveys.
Approach: Ultra-sensitive nucleic acid based detection methods for P. falciparum and P. vivax will be developed by targeting highly repetitive DNA markers and highly expressed stage-specific transcripts. Ultra-low density infections will be studied in different endemic settings and age groups, for P. vivax we compare PNG (high transmission), Thailand (low transmission) and Brazil (close to elimination). Gametocyte detection and genotyping in both species will be used for estimating the transmission potential and transmission dynamics.","Basic science, Operational research","Asymptomatic reservoir, Measurement of transmission, P. vivax, Parasite genetic diversity, Tools for elimination"