"Title","URL","Type","Start year","End year","Countries","Project funding","Funding source(s)","Funding information","Partner(s)","PI institution(s)","Principal investigator","Abstract","Objectives","Methodology","Themes"
"Evaluation of alternative therapeutic schemes for treatment of uncomplicated P. vivax malaria ","http://www.malariaeradication.org/mesa-track/evaluation-alternative-therapeutic-schemes-treatment-uncomplicated-p-vivax-malaria","Project","Jan 2011","Dec 2012","Brazil","","","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Monica Regina Farias Costa","","","Product development & clinical research","P. vivax"
"Serological assessment in patients with uncomplicated P. vivax malaria treated with Chloroquine","http://www.malariaeradication.org/mesa-track/serological-assessment-patients-uncomplicated-p-vivax-malaria-treated-chloroquine","Project","Jan 2011","Dec 2012","Brazil","","","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Marly Melo","","","Epidemiology, Product development & clinical research","P. vivax"
"Molecular characterization of G6PD deficiency of individuals in Manaus ","http://www.malariaeradication.org/mesa-track/molecular-characterization-g6pd-deficiency-individuals-manaus","Project","Jan 2008","Dec 2012","Brazil","","","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Maria Das Gracas Costa Alecrim","","","Epidemiology, Operational research","P. vivax"
"Serological evaluation of patients with P. vivax malaria treated with Chloroquine and primaquine","http://www.malariaeradication.org/mesa-track/serological-evaluation-patients-p-vivax-malaria-treated-chloroquine-and-primaquine","Project","Jan 2011","Dec 2012","Brazil","","","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Eva Batista de Caralho","","","Epidemiology, Product development & clinical research","Drug-based strategies, P. vivax"
"Analysis of malaria transmission dynamics in peri-urban area of Manaus from 2003 to 2012","http://www.malariaeradication.org/mesa-track/analysis-malaria-transmission-dynamics-peri-urban-area-manaus-2003-2012","Project","Aug 2012","Jul 2013","Brazil","","Amazonas State Research Support Foundation (FAPEAM), Brazil","","Amazonas Health Surveillance Foundation","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil, University of the State of Amazonas, Brazil","André Machado Siqueira ","","1. To describe the change in malaria transmission dynamics in a 10-year-period in a peri-urban area in the Brazilian Amazon.
2. To analyze factors associated with changing malaria epidemiology.
3. To investigate changes on malaria incidence following the inauguration of the bridge over the Negro river.","Epidemiology","Measurement of transmission, Surveillance"
"Efficacy of artemether + lumefantrine in treatment of uncomplicated Pf malaria and evaluation of in vitro susceptibility ","http://www.malariaeradication.org/mesa-track/efficacy-artemether-lumefantrine-treatment-uncomplicated-pf-malaria-and-evaluation-vitro","Project","Aug 2011","Jul 2013","Brazil","$65 636","Coordination for the Improvement of Higher Education Personnel (CAPES), Brazil","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Maria Das Gracas Costa Alecrim","","","Product development & clinical research","Drug resistance, Drug-based strategies"
"A randomized comparative study to assess the effectiveness and tolerability of artesunate-amodiaquine versus chloroquine for uncomplicated P. vivax malaria","http://www.malariaeradication.org/mesa-track/randomized-comparative-study-assess-effectiveness-and-tolerability-artesunate-amodiaquine","Project","Jan 2011","Dec 2013","Brazil","$335 429","","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Marcus Vinícius G. de Lacerda","","","Product development & clinical research","P. vivax"
"Malaria systems biology a model for interaction pathogen-host","http://www.malariaeradication.org/mesa-track/malaria-systems-biology-model-interaction-pathogen-host","Project","Jan 2014","Dec 2016","","$18 435","","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Marcus Vinícius G. de Lacerda","","","Basic science","Other"
"A study to evaluate the efficacy, safety and tolerability of tafenoquine (TQ) in subjects with plasmodium vivax in Brazil as part of detective multicentre trial.","http://www.malariaeradication.org/mesa-track/study-evaluate-efficacy-safety-and-tolerability-tafenoquine-tq-subjects-plasmodium-viva-0","Project","Jan 2011","Mar 2015","Brazil","","GlaxoSmithKline (GSK) ","","Medicines for Malaria Venture (MMV), Mahidol University, Cayetano Heredia University, Peru","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Marcus Vinícius G. de Lacerda","","To assess the dose-response, safety, and tolerability of single-dose tafenoquine plus 3-day chloroquine for P vivax malaria radical cure.","Product development & clinical research","P. vivax"
"Efficacy of antimalarial drugs in combination with primaquine to treat uncomplicated P. vivax malaria ","http://www.malariaeradication.org/mesa-track/efficacy-antimalarial-drugs-combination-primaquine-treat-uncomplicated-p-vivax-malaria","Project","Jan 2013","Dec 2014","Brazil","$176 573","Ministry of Health (MOH) Brazil","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Franklin Simoes","","","Product development & clinical research","Drug-based strategies, P. vivax"
"Diagnosis of G6PD deficiency in P. vivax patients","http://www.malariaeradication.org/mesa-track/diagnosis-g6pd-deficiency-p-vivax-patients","Project","Aug 2013","Mar 2015","Brazil","$8 667","Amazonas State Research Support Foundation (FAPEAM), Brazil","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Marcus Vinícius G. de Lacerda","","","Operational research","P. vivax"
"Ivermectin for reducing malaria transmission: evaluation of an innovative tool in the Brazilian Amazon","http://www.malariaeradication.org/mesa-track/ivermectin-reducing-malaria-transmission-evaluation-innovative-tool-brazilian-amazon","Project"," 2014","","Brazil","","Amazonas State Research Support Foundation (FAPEAM), Brazil","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Wuelton Marcelo Monteiro","The objective of this study is to evaluate the impact of the administration of ivermectin on vectors transmitting malaria in order to determine the effectiveness of this drug as an innovative and additional tool in the integrated malaria control. It is expected that ivermectin help to overcome the important challenges posed by malaria vectors: (1) its mode of action is different from classes of insecticides currently used, bypassing the emergence of resistance to insecticides, (2) it is as a systemic drug, it is ingested by all biting mosquitoes, reaching also those with endo- and exofágico behavior, and (3) the drug's activity targets the main variable of vectorial capacity, which is the probability of mosquito daily survival. 
This study will allow the generation of more reliable evidence and will lead to increased experience of the research group in this type of methodology. 
","","Entomology, Operational research","Drug-based strategies, Residual transmission, Tools for elimination"
"Population-based survey to estimate the prevalence of G6PD deficiency in the Brazilian Amazon and cost-effectiveness of a RDT to detect G6PDd in malaria patients","http://www.malariaeradication.org/mesa-track/population-based-survey-estimate-prevalence-g6pd-deficiency-brazilian-amazon-and-cost","Project"," 2013","","Brazil","","Ministry of Health (MOH) Brazil","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Marcus Vinícius G. de Lacerda","In this work, we intend to estimate the prevalence of G6PDd and the relative frequency of deficient variants in the states that comprise the Legal Amazon and conduct a cost-effectiveness analysis of the use of rapid test to detect G6PDd in patients with P. vivax malaria in an endemic malaria area in the Amazon, Brazil.
For this, a cross-sectional study will be conducted, with cluster sampling, involving all municipalities of the Legal Amazon with active transmission of malaria. Males will be investigated by fluorescent spot test test for phenotyping G6PD deficiency. Those with deficient phenotype will be genotyped using the RFLP technique for the search of the main mutations found in Brazil (African and Mediterranean).
For the second goal, it will be constructed a decision-analysis model for the use of rapid tests for detecting G6PDd, in an endemic area for malaria, compared with ""no test"" in routine malaria program. This work will also allow for determining the costs of introducing the rapid test for the detection of cases of G6PDd in an endemic area for malaria and the ratio of incremental cost-effectiveness in case of deficiency detected by comparing the different tests available to current routine Malaria Program .
This study will fulfill the complex task of characterizing the distribution and diversity of G6PD variants in order to contribute to health policy based on evidence for the use of primaquine. In addition, it will generate important evidence for the incorporation of the rapid test for detecting G6PDd among patients with malaria in the National Program for Malaria Control, from the cost-effectiveness results, identifying priority scenarios for its incorporation
","","Epidemiology, Operational research","P. vivax, Tools for elimination"
"Evaluation of new tools for the control and surveillance of malaria transmission: integration with the treatment of other diseases and xenosurveillance using non-anopheline mosquitoes","http://www.malariaeradication.org/mesa-track/evaluation-new-tools-control-and-surveillance-malaria-transmission-integration-treatment","Project"," 2012","","Brazil","","National Council for Scientific and Technological Development, Brazil","","","Doctor Heitor Vieira Dourado Foundation for Tropical Medicine (FMT-HVD), Brazil","Wuelton Marcelo Monteiro","We intend to investigate whether the DNA against the rate of Plasmodium sp. in mosquitoes is associated with the frequency of malaria in an endemic area of ??the disease, located on the outskirts of the Municipality of Manaus. 
This is an Ecological Study to be held on extensions of Brasileirinho, the Puraquequara and Ipiranga. It will include collections of adult mosquitoes inside the home, using entomological electric vacuum cleaner and the BG-Sentinel® trap. The identification of the species of mosquitoes will be conducted using dichotomous keys and will study the frequency and diversity of the species of mosquitoes found. 
","","Entomology, Operational research","Measurement of transmission, Surveillance"